Kidney
1. Photodynamic Therapy in Urology: What Can We Do Now and Where Are We Heading?
Background: Photodynamic therapy (PDT) is an innovative technique in oncologic urology. Its application appears increasingly realistic to all kind of cancers with technological progress made in treatment planning and light delivery associated with the emergence of novel photosensitizers. The aim of this study is to review applications of this technique in urologyConclusion: PDT clinical applications in urology have proved a kind of efficiency balanced with an important morbidity. Development of new photosensitizer generations and improvement in illumination protocols should permit to decrease side effects
For renal cancer, PDT was only tested on preclinical model despite of its potential application.
2. Photoirradiation After Aminolevulinic Acid Treatment Suppresses Cancer Cell Proliferation Through the HO-1/p21 Pathway
HEK293 human embryonic kidney cells, MKN45 human gastric cells, and PC-3 human prostate cancer cells were selected for this research Conclusion: ALA-PDD or ALA-PDT can result in rapid ROS-induced cell death and may decrease long-term recurrence rates through several pathways including the HO-1/p21 pathway