Colon and Rectum
1. Use of Photodynamic Therapy in Malignant Lesions of Stomach, Bile Duct, Pancreas, Colon and Rectum
Photodynamic therapy (PDT) using sensitizer, light and oxygen can induce malignant cells to death and treat non-cancerous conditions. It is a predominant and attractive endoscopic technique which could palliate advanced gastrointestinal cancer and eradicate early neoplastic and pre-neoplastic lesions. After PDT, cells may become apoptotic or necrotic which depends on photosensitizer, dose and cells' genotype. Photosensitizers, used in PDT, are accumulated in mitochondria. This is the mechanism of cell death both in vitro and in vivo. In review we summarize the clinical use of PDT in malignant lesions of stomach, bile duct, pancreas, colon and rectum with various photosensitizers. Especially, porfimer sodium, a PDT photosensitizer, has been confirmed as a potent treatment in cholangiocarcinoma.
2. Effects of Chlorin e6-mediated Photodynamic Therapy on Human Colon Cancer SW480 Cells
Conclusion: Ce6-PDT treatment could enhance ROS production and apoptosis, inhibit cell proliferation, decrease migration ability and colony formation ability, in SW480 cells, in a dose-dependent manner. These findings might provide experimental evidence for the application of Ce6-PDT in clinical treatment of colorectal cancer.